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文献和实验Animal Models of Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the selective death of motor neurons. Although ALS is predominantly a disease of motor system degeneration, cognitive impairments have also been reported
Stem Cell Transplantation for Spinal Cord Neurodegeneration
Amyotrophic lateral sclerosis (ALS), a disorder that affects 30,000 individuals in the USA alone, is characterized by relatively rapid degeneration of upper and lower motor neurons, with death normally occurring 2–5 years following diagnosis
Application of Viral Vectors to Motor Neuron Disorders
Motor neuron diseases such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) are characterized by the progressive loss of motor neurons in the spinal cord and primary motor cortex. Subsequent paralysis of skeletal
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