重组人二氢硫辛酰胺S-乙酰转移酶

产品英文名称：
Recombinant Human Dihydrolipoamide S-Acetyltransferase

英文简称:
DLAT

中文名称:
重组人二氢硫辛酰胺S-乙酰转移酶

背景资料:
DLAT gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex（PDC). PDC is located in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene， dihydrolipoamide acetyltransferase， takes acetyl groups created by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies which are found in about 95% of patients with the autoimmune liver disease primary biliary cirrhosis（PBC). In patients who suSf9昆虫细胞重组表达er from this illness， activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC ultimately leads to cirrhosis and liver failure. Mutations in DLAT are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.

产品描述:
DLAT is a full-length cDNA coding for the mature form of the human PDC-E2 protein having a molecular mass of 60，630 Dalton（pH 5.8). DLAT protein is fused to a hexa-histidine purification tag.
来源宿主:
Sf9昆虫细胞重组表达

序列:


溶解建议:
提供的重组人二氢硫辛酰胺S-乙酰转移酶产品形式为无菌的无色溶液.

保存建议：
人二氢硫辛酰胺S-乙酰转移酶蛋白产品可于4℃可保存2-4周. 长期保存，请置于-20℃. 请避免反复冻融.
其他简介：

  ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际一流的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。
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