- ￥398
- 戴格
- 浙江杭州
- db12143
- 2026年02月04日
- WB, IHC-P, ICC/IF
- Rabbit
- Human,Mouse,Rat
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- 详细信息
- 技术资料
- 免疫原：
A synthetic peptide of human Axin 2
- 亚型：
IgG
- 保存条件：
Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
- 克隆性：
Monoclonal
- 适应物种：
Human,Mouse,Rat
- 库存：
99
- 宿主：
Rabbit
- 应用范围：
WB, IHC-P, ICC/IF
- 靶点：
Axin 2
- 规格：
10μl
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]
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技术资料暂无技术资料 索取技术资料
Axin 2 (DGR13699) Rabbit mAb
￥398
