- ￥2200
- Biorigin
- BN40468R
- 2026年04月11日
- WB,
- Human,Mouse,Rat,Chicken,Dog,Cow,Horse,
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- 详细信息
- 文献和实验
- 技术资料
- 适应物种：
Human,Mouse,Rat,Chicken,Dog,Cow,Horse,
- 应用范围：
WB,
- 抗体英文名：
phospho-alpha Adducin (Ser436)
- 规格：
100ul
| 英文名称 | phospho-alpha Adducin (Ser436) |
| 中文名称 | 磷酸化内收蛋白a1抗体 |
| 别 名 | alpha Adducin(phospho S436); alpha Adducin(phospho Ser436); p-alpha Adducin(S436); p-alpha Adducin(Ser436); ADD 1; ADD A; ADD1; ADD1 protein; ADDA; ADDA_HUMAN; Adducin 1 (alpha); Adducin 1 alpha; Alpha adducin; Alpha-adducin; Erythrocyte adducin alpha subunit; Erythrocyte hosphor subunit alpha; Erythrocyte adducin subunit alpha. |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 细胞生物 信号转导 激酶和磷酸酶 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, (predicted: Rat, Chicken, Dog, Cow, Horse, ) |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 81kDa |
| 细胞定位 | 细胞浆 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthesised phosphopeptide derived from human alpha Adducin around the phosphorylation site of Ser436:RH(p-S)FQ |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | Adducins are a family of cytoskeleton proteins encoded by three genes (Alpha, Beta, Gamma). Adducin is a protein associated with the inner leaflet of the plasma membrane and is one of the proteins localized at the spectrin-actin junction of the membrane skeleton. The cortical actin cytoskeletal network is lost during apoptosis and Adducins are central in the cortical actin network organization. Adducin Alpha is a cytoskeletal protein involved with sodium-pump activity in the renal tubule and is associated with hypertension. The expression of Adducin Alpha and Adducin Gamma is ubiquitous in contrast to the restricted expression of Adducin Beta. Adducin Beta is expressed at high levels in brain and hematopoietic tissues, such as bone marrow, in humans, and in spleen in mice. Function: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. Subunit: Heterodimer of an alpha and a beta subunit or an alpha and a gamma subunit. Subcellular Location: Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Tissue Specificity: Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit. Similarity: Belongs to the aldolase class II family. Adducin subfamily. SWISS: P35611 Gene ID: 118 Database links: Entrez Gene: 118 Human Entrez Gene: 11518 Mouse Omim: 102680 Human SwissProt: P35611 Human SwissProt: Q9QYC0 Mouse Unigene: 183706 Human Unigene: 289106 Mouse Unigene: 5788 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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举例。 表23-5 用基因作探针检测基因内的结构变化来直接分析遗传病 遗传病 探针 年代 抗凝血酶Ⅲ缺乏症 抗凝血酶Ⅲ基因 1983 α1抗胰蛋白酶缺乏症 合成的寡核苷酸 1983 动脉粥样硬化症 载脂蛋白A-基因 1983 糖尿病 胰岛素基因 1983 Ehlers-Danlos综合症 α（1）胶原蛋白基因 1983 生长激素缺乏症 生长激素基因 1981 乙型血友病 凝血因子ⅠⅩ基因 1983 遗传性胎儿血红蛋白持存症 β珠蛋白基因 1979，1983 HPRT
Sca-1被广泛认为和Ly-6 半抗原一起，是小鼠HSC标志分子，它在多能HSCs上表达。一种抗Sca-1抗体经常和一些细胞表面标志分子表达的阴性选择一起用来鉴定和分离小鼠HSCs. Sca-1+ HSCs可在成年骨髓、胎儿肝脏、成年动物流动的外周血和脾脏中被找到。Sca-1在几种非造血组织中也被发现。43可用来富集HSCs之外的祖细胞。Sca-1 可能参与调节B细胞和T细胞活化。 间质干细胞的标志物 STRO-1: 用CD34阳性骨髓细胞进行免疫产生的小鼠IgM单抗STRO-1, 能识别
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