- ￥1200
- Biorigin
- BN41679R
- 2026年04月22日
- WB,
- Human,Mouse,Rat,Chicken,Pig,Cow,Horse,Sheep,
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- 详细信息
- 文献和实验
- 技术资料
- 适应物种：
Human,Mouse,Rat,Chicken,Pig,Cow,Horse,Sheep,
- 应用范围：
WB,
- 抗体英文名：
GDF8
- 规格：
50ul
| 英文名称 | GDF8 |
| 中文名称 | 生长分化因子8抗体 |
| 别 名 | GDF 8; GDF-8; GDF8_HUMAN; Growth differentiation factor 8; Growth/Differentiation Factor 8; MSTN; myostatin; OTTHUMP00000163498. |
| 研究领域 | 免疫学 生长因子和激素 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse, Rat, (predicted: Human, Chicken, Pig, Cow, Horse, Sheep, ) |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 12/43kDa |
| 细胞定位 | 分泌型蛋白 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GDF8:281-375/375 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth. Acts specifically as a negative regulator of skeletal muscle growth. [SUBUNIT] Homodimer; [TISSUE SPECIFICITY] Expressed specifically in developing and adult skeletal muscle. Weak expression in adipose tissue. Belongs to the TGF-beta family. Function: Acts specifically as a negative regulator of skeletal muscle growth. Subunit: Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FST3. Subcellular Location: Secreted Tissue Specificity: Predominantly expressed in muscle. At hatching, expression is strongest in the skin epithelium, and is also found in the retina and brain. From day 28, expressed in skeletal muscle. In the adult, highest expression is seen in the gastrointestinal tract, brain, muscle, heart and testis. Also expressed in the adult pharynx, kidney, spleen, liver, gill, eyes, skin, swim bladder and ovary. DISEASE: Defects in MSTN are the cause of muscle hypertrophy (MSLHP) [MIM:614160]. MSLHP is a condition characterized by increased muscle bulk and strength. Affected individuals are exceptionally strong. Similarity: Belongs to the TGF-beta family. SWISS: O14793 Gene ID: 2660 Database links: Entrez Gene: 2660 Human Entrez Gene: 17700 Mouse Entrez Gene: 373964 Chicken Entrez Gene: 798441 Zebrafish Omim: 601788 Human SwissProt: O14793 Human SwissProt: O08689 Mouse SwissProt: O18830 Sheep SwissProt: O42222 Zebrafish Unigene: 41565 Human Unigene: 3514 Mouse Unigene: 44460 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. GDF-8又称MSTN,是转化生长因子超家族，也是近年来发现的一类重要的肌细胞生长调控因子，它通过抑制MyoD家族成员转录活性负向控制肌细胞的生长发育，它的表达量与肌肉重量的变化呈负相关。 |
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人生长分化因子-15(GDF-15)ELISA试剂盒 说明书
上海西唐生物科技有限公司 021-55229872, 65333639 www.westang.com 人生长分化因子-15 ( GDF-15 )ELISA 试剂盒 ( 用于血清、血浆、细胞培养上清液和其它生物体液内 ) 原理 本实验采用双抗体夹心 ABC-ELISA 法。用抗人 GDF-15 单抗包被于酶标板上，标准品和样品中的 GDF-15与单抗结合，加入生物
Notch家族的4个受体是广泛表达的跨膜蛋白，哺乳动物细胞通过它们进行沟通，来调控细胞命运和生长。Notch信号作用的缺陷与很多癌症相关，包括急性淋巴细胞白血病。利用“噬菌体呈现技术”，“基因科技公司”一个多学科小组生成了合成抗体，它们是Notch1 和Notch2的强效和特异性拮抗剂。抗Notch1的抗体在临床前小鼠模型中表现出抗肿瘤活性，能抑制癌细胞生长和血管生成，并且在培养中也表现出针对人类癌细胞的活性。 Notch1和Notch2的同时抑制会引起小肠毒性，而只抑制其中一个能在很大
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