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Fibrinogen, Biotin conjugated

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  • 询价
  • Agrisera
  • 瑞典
  • IMS06-038-312
  • 2026年02月03日
  • 1 : 5000 (WB)
  • Chicken
  • Human
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 免疫原

      Purified, full length native fibrinogen UniProt: Q9UE34

    • 形态

      Liquid in 0.15M sodium chloride, 0.02M sodium phosphate, 0.1% sodium azide, pH 7.2

    • 保存条件

      Store at 4°C; make aliquots to avoid working with

    • 克隆性

      Polyclonal

    • 标记物

      Kinzebach et al. (2013). Functional and differential proteomic analyses to identify platelet derived factors affecting ex vivo expansion of mesenchymal stromal cells. BMC Cell Biol. 2013 Oct 30;14(1):48.

    • 适应物种

      Human

    • 抗原来源

      Q9UE34

    • 级别

      分子生物学级

    • 供应商

      Agrisera

    • 宿主

      Chicken

    • 应用范围

      1 : 5000 (WB)

    • 靶点

      Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bon

    • 抗体英文名

      Only one precipitation arc in immunodiffusion and immunoelectrophoresis against normal human plasma or human fibrinogen.

    • 抗体名

      Fibrinogen, Biotin conjugated

    • 规格

      100 µl

    Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N-terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel et al. 2000; Rapold et al. 1989).

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