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- 详细信息
- 文献和实验
- 技术资料
- 适应物种:
Human,Mouse,Rat,Pig,Cow,Horse,Rabbit,
- 应用范围:
FCM,
- 抗体英文名:
TAAL6
- 规格:
100ul
| 英文名称 | TAAL6 |
| 中文名称 | 肿瘤相关蛋白抗原L6抗体 |
| 别 名 | M3S1; Membrane component chromosome 3 surface marker 1; T4S1_HUMAN; TAAL6; Tm4sf1; Transmembrane 4 L6 family member 1; Tumor-associated antigen L6. |
| 研究领域 | 肿瘤 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, (predicted: Mouse, Rat, Pig, Cow, Horse, Rabbit, ) |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=2ug/Test IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 24kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Transmembrane 4 L6 family member 1:21-120/202 <Extracellular> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. [provided by RefSeq, Jul 2008] Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Highly expressed in lung, breast, colon and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular. Similarity: Belongs to the L6 tetraspanin family. SWISS: P30408 Gene ID: 4071 Database links: Entrez Gene: 4071 Human Entrez Gene: 17112 Mouse Omim: 191155 Human SwissProt: P30408 Human SwissProt: Q64302 Mouse Unigene: 351316 Human Unigene: 856 Mouse Unigene: 24712 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |


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文献和实验有VEGF及其受体的过高表达。更为可喜的是,与传统治疗相比,VEGF和/或其受体的拮抗剂可能对肿瘤有较高的特异性,减少副作用,因避开肿瘤细胞耐药机制切断肿瘤细胞的血液供应会降低耐药的发生。近年来的研究表明,KDR/Flk-1受体由于数目少,表达于细胞表面等特点而更适于作为抑制血管新生的靶点。目前,至少三种抗体作为抗血管新生治疗剂正处于积极地研究中,其中两个正进行临床试验以评价其抗肿瘤能力。RhuMAB VEGF是一种人源化的抗VEGF抗体正处于II/III期临床试验用于治疗肺癌、乳腺癌、前列腺癌和直肠
糖类抗原242(CA-242)检测的临床意义: CA-242是一种新型的肿瘤标志物,是一种粘蛋白糖类抗原,1985年由Lindholm等人发现,它是人结-直肠癌细胞株Colo205经杂交瘤技术免疫小鼠获得的单克隆抗体CA-242所能识别的一种抗原,其抗原决定簇是一种新的唾液酸化的糖。免疫化学研究证明,CA-242不同于现有的肿瘤相关粘蛋白抗原,如CA-199,CA-50等。CA-242抗原决定簇的表达如同唾液酸化路易思A抗原(例如CA199)SialyLewis(SLea
糖类抗原242检测的临床意义: CA-242是一种新型的肿瘤标志物,是一种粘蛋白糖类抗原,1985年由Lindholm等人发现,它是人结-直肠癌细胞株Colo205经杂交瘤技术免疫小鼠获得的单克隆抗体CA-242所能识别的一种抗原,其抗原决定簇是一种新的唾液酸化的糖。免疫化学研究证明,CA-242不同于现有的肿瘤相关粘蛋白抗原,如CA-199,CA-50等。CA-242抗原决定簇的表达如同唾液酸化路易思A抗原(例如CA199)SialyLewis(SLea)一样,是在粘蛋白
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