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- 详细信息
- 文献和实验
- 技术资料
- 英文名:
Biotinylated Recombinant Human PCSK9 (C-Avi)
- 规格:
20ug/100ug
| 规格: | 20ug | 产品价格: | ¥2300.0 |
|---|---|---|---|
| 规格: | 100ug | 产品价格: | ¥6210.0 |
Biotinylated Recombinant Human PCSK9 (C-Avi) (CA84)
产品说明(Description)
Biotinylated Recombinant Human Proprotein Convertase Subtilisin/Kexin Type 9 is produced by ourMammalian expression system and the target gene encoding Gln31-Gln692(Val474Ile,Gly670Glu) isexpressed with a Avi tag at the C-terminus.
Accession #: Q8NBP7
Known as: Proprotein Convertase Subtilisin/Kexin Type 9; Neural Apoptosis-Regulated Convertase 1; NARC-1; Proprotein Convertase 9; PC9; Subtilisin/Kexin-Like Protease PC9; PCSK9; NARC1
制剂(Formulation)
Supplied as a 0.2 μm filtered solution of 50mM HEPES,150mM NaCl,20%Glycerol,pH 7.4.
质量控制(Quality Control)
Purity: Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin: Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
Biotin:Protein Ratio The biotin to protein ratio is 0.5-1 as determined by the HABA assay.
运输(Shipping)
The product is shipped on dry ice/polar packs.
Upon receipt, store it immediately at the temperature listed below.
保存(Storage)
Store at ≤-70°C, stable for 6 months after receipt.
Store at ≤-70°C, stable for 3 months under sterile conditions after opening.
Please minimize freeze-thaw cycles.
背景(Background)
Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2), and play a role in the neural development.
电泳(SDS-PAGE)
FOR RESEARCH USE ONLY
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