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- 2026年01月30日
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Anti-Tau-tubulin kinase 2 (TTBK2)
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文献和实验14-3-3 is a potent inhibitor of protein kinase C, but the N-terminal domain does not inhibit PKC activity. Site-specific mutagenesis of several regions in the tau isoform of 14-3-3, including the mutation of a putative pseudosubstrate site
and CDK5/p25, two protein kinases involved in abnormal tau phosphorylationin Alzheimer’s disease. A propertycommon to most cyclin-dependent kinase inhibitors? J Biol Chem. 276 , 251–260. 20. Leost M, Schultz C, Link A, et al. (2000)Paullones
Introduction of human 14-3-3 proteins
inhibitor of protein kinase C,but the N-terminal domain does not inhibit PKC activity.Site-specific mutagenesis of several regions in the tau isoform of 14-3-3,including the mutation of a putative pseudosubstrate site to a potential substrate sequence
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