GALR2 Polyclonal Antibody

Verified Samples in IHC: Human cervical cancer, Human colorectal cancer

IHC 1:30-1:150

Polyclonal

IgG

Synthetic peptide of human GALR2

GALR2

GAL2-R, GAL2R, GALNR2, GALR-2, GALR2, Galanin receptor 2, Galanin receptor type 2, MGC125983, MGC125984

O43603

Cell membrane.

0.66 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% NaN3 and 40% Glycerol, pH 7.4.

Antigen affinity purification

Metabolism, Neuroscience

Unconjugated

GALR2 (Galanin Receptor 2) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and galanin receptor activity. An important paralog of this gene is GALR3.Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways.