人IL1R2重组蛋白Interleukin-1 recept

英文名称：

Recombinant Human Interleukin-1 receptor type 2 (IL1R2), partial (Active)

品名简称：

Recombinant Human IL1R2 protein, partial (Active)

货号：

CSB-MP011622HU1

规格:

20μg

价格：

696

LC-MS/Western Blot：

The purity of IL1R2 was greater than 90% as determined by SEC-HPLC

SDS-PAGE：

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

纯度：

Greater than 95% as determined by SDS-PAGE. Greater than 90% as determined by SEC-HPLC.

内毒素：

Less than 1.0 EU/μg as determined by LAL method.

生物活性：

Measured by its binding ability in a functional ELISA.Immobilized Human IL1B(CSB-MP011614HU) at 5 μg/mL can bind Human IL1R2. The EC50 is 89.65-100.5 ng/mL.

基因名：

IL1R2

Uniprot No.：

P27930

别名：

Interleukin-1 receptor type 2; IL-1R-2; IL-1RT-2; IL-1RT2; CD121 antigen-like family member B; CDw121b; IL-1 type II receptor; Interleukin-1 receptor beta (IL-1R-beta); Interleukin-1 receptor type II; Interleukin-1 receptor type 2, membrane form (mIL-1R2; mIL-1RII); Interleukin-1 receptor type 2, soluble form (sIL-1R2; sIL-1RII); CD121b; IL1R2; IL1RB

种属：

Homo sapiens (Human)

蛋白长度：

Partial

来源：

Mammalian cell

分子量：

65.3 kDa

表达区域：

14-343aa

氨基酸序列：

FTLQPAAHTGAARSCRFRGRHYKREFRLEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYPGGRVTEGPRQEYSENNENYIEVPLIFDPVTREDLHMDFKCVVHNTLSFQTLRTTVKE

蛋白标签：

C-terminal hFc1-tagged

产品提供形式：

Lyophilized powder

缓冲液：

Lyophilized from a 0.2 μm sterile filtered PBS, 6% Trehalose, pH 7.4

储存条件：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

保质期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.

货期：

3-7 business days

注意事项：

Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.

功能1：

Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

功能2：

/

文献：

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Wilson R.K. Nature 434:724-731 (2005)

研究领域：

Immunology

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