alpha-Helical Corticotropin Re

Characterization of Corticotropin‐Releasing Factor (CRF) Receptors

) 6 µM unlabeled rat/human corticotropin‐releasing factor (r/hCRF; Peninsula Labs) or D‐Phe r/hCRF(12‐41) (Rivier et al., ) in recipeassay buffer 6× radioligand

Determining the Activation of Rho as an Index of Receptor Coupling to G12/13 Proteins

their own signal transduction pathways. G proteins are functionally divided into four groups based on the nature of α subunit into Gs , Gi , Gq , and G12 families. The members of the G12 subfamily are G12 and G13 . Increasing evidence indicates that G12/13 proteins

促肾上腺皮质激素释放因子 corticotropinreleasing factor

　　缩写 CRF。在所谓的促激素释放因子（ RF）中，是最早肯定其存在的（ A． V． Schally等， 1955），是通过丘脑下部 -脑垂体神经分泌系统分泌进入垂体门静脉系统，它直接作用于腺垂体的促肾上腺皮御素（ ACTH）分泌细胞，促进 ACTH（别名 corticotropin）的分泌。有α 1 -、α 2 -和β -CRF三种，类似多肽，但详细化学性质尚不清楚。也可从丘脑下部和神经垂体中提取。