细胞穿膜肽LK15、LK15 Cell-Penetratin

7.15 干细胞也会“近墨者黑”？

周一，柚子酱依然爱你。①干细胞也会“近墨者黑”？赫尔辛基大学的研究人员发现，以抑制干细胞维持信号的酶为靶点，可以使老化肠的再生潜能恢复。这一发现可能为缓解与衰老相关的胃肠道问题、减少癌症治疗的副作用以及通过促进康复来降低老龄化社会的医疗成本开辟道路。“这项研究强调了细胞相互作用的重要性。一个细胞的内部变化导致了一种衰老因子的分泌，这种因子可以作为药物的靶标，为干预提供多个有用的靶点，”赫尔辛基大学和卡罗林斯卡学院的副教授，该项目的主要研究者Pekka Katajisto说。原文检索：Notum

Cellular Delivery of Peptide Nucleic Acid by Cell-Penetrating Peptides

different types of delivery vectors (receptor ligands and cellpenetrating peptides) and strategies for the design and synthesis of PNA-vector conjugates. A protocol for the delivery of antisense PNA oligomer-cell-penetrating peptide conjugates

Improved Cellular Uptake of Antisense Peptide Nucleic Acids by Conjugation to a Cell-Penetrating Peptide and a Lipid Domain

. Recently, a novel approach using a class of short cationic peptides known as cell-penetrating peptides (CPPs) is attracting wide attention for a variety of biologically active molecules. CPP-mediated delivery is typically based on the covalent conjugation