Haptoglobin 重组人触珠蛋白 人源重组蛋白 细胞因

Human Haptoglobin Protein, His tag (重组人触珠蛋白)

货号: PRP1078 | 产品类型: 重组细胞因子

产品概述

本产品为重组人源触珠蛋白（Human Haptoglobin Protein），带有His标签，通过大肠杆菌表达系统重组表达并经高纯度纯化制备。该蛋白序列来源于人触珠蛋白（UniProt ID: P00738）的Ile162-Asn406片段，由245个氨基酸组成，预测分子量为29.5 kDa。产品以冻干粉形式提供，纯度超过95%，适用于多种细胞培养及科学研究应用。

关键特性

• 高纯度：经SDS-PAGE验证，纯度 > 95%
• 低内毒素：LAL法检测内毒素含量 < 0.1 EU/μg
• 无动物源成分：大肠杆菌表达，避免外源病原污染风险
• 严格质量控制：每批产品均经过严格的质控检测，确保实验的一致性与可重复性

产品信息

表达宿主	大肠杆菌
蛋白长度	245个氨基酸
预测分子量	29.5 kDa
标签	N端6×His标签
种属来源	人
产品形式	冻干粉（冻干缓冲液：无菌PBS, pH 7.4）

应用方向（研究用途）

• 细胞培养与分化研究
• 血红蛋白清除机制研究
• 急性期炎症反应相关信号通路研究
• 作为标准品用于蛋白定量或抗体检测

使用建议

开盖前请离心。推荐使用配套复溶缓冲液（Reconstitution Buffer）复溶至浓度不低于100 µg/mL。可根据实验需求进一步稀释。为避免降解，建议在含有载体蛋白（如0.1% HSA或BSA）的缓冲液中进行稀释和保存。

保存与运输

保存条件：冻干粉可在-20°C下稳定保存1年；复溶后于2°C–8°C可保存1周，稀释后分装存于-20°C或-80°C可保存3–6个月，应避免反复冻融。

运输条件：冰袋运输（蓝冰）。

背景介绍

触珠蛋白（Haptoglobin）是一种主要由肝脏合成的糖蛋白，作为一种阳性急性期蛋白，在炎症反应中显著上调。其通过与游离血红蛋白结合形成复合物，介导其清除，从而防止肾脏损伤及铁流失。研究表明，Haptoglobin的表达水平与溶血性疾病、肝脏功能、糖尿病肾病、冠状动脉疾病及炎症性疾病等多种生理和病理过程密切相关。

规格与价格

规格	价格（元）	货期
5 µg	588	现货（次日发货）
20 µg	1498	现货（次日发货）
100 µg	5698	现货（次日发货）
1 mg	请咨询	请咨询

注意：本产品仅供研究使用，不适用于人类或临床诊断。

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注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

Human Haptoglobin Protein, His tag (Recombinant Human Haptoglobin)

Item No.: PRP1078 | Product Type: Recombinant Cytokine

Product Overview

This product is a recombinant human haptoglobin protein (Human Haptoglobin Protein) bearing a His‑tag, expressed in an Escherichia coli system and purified to high purity. The protein sequence corresponds to the Ile162‑Asn406 fragment of human haptoglobin (UniProt ID: P00738), comprising 245 amino acids with a predicted molecular weight of 29.5 kDa. The product is supplied as a lyophilized powder, with purity >95%, suitable for a variety of cell‑culture and scientific‑research applications.

Key Features

• High Purity: SDS‑PAGE confirmed purity >95%
• Low Endotoxin: LAL assay endotoxin level < 0.1 EU/µg
• Avoids Animal‑Derived Components: Produced in E. coli, eliminating risk of exogenous pathogen contamination
• Stringent Quality Control: Each batch undergoes rigorous QC testing to ensure experimental consistency and reproducibility

Product Information

Expression Host	Escherichia coli
Protein Length	245 amino acids
Predicted Molecular Weight	29.5 kDa
Tag	N‑terminal 6×His tag
Species Source	Human
Product Form	Lyophilized powder (lyophilization buffer: sterile PBS, pH 7.4)

Applications (Research Use Only)

• Cell culture and differentiation studies
• Hemoglobin clearance mechanism investigations
• Acute‑phase inflammatory signaling pathway research
• Use as a standard for protein quantification or antibody detection

Recommended Use

Spin down the vial before opening. It is recommended to reconstitute with the provided Reconstitution Buffer to a concentration of at least 100 µg/mL. Further dilutions can be made according to experimental needs. To prevent degradation, dilute and store in a buffer containing a carrier protein (e.g., 0.1 % HSA or BSA).

Storage and Shipping

Storage Conditions: Lyophilized powder remains stable at –20 °C for up to 1 year; after reconstitution, store at 2 °C–8 °C for 1 week. Aliquoted, diluted samples can be stored at –20 °C or –80 °C for 3–6 months. Avoid repeated freeze‑thaw cycles.

Shipping Conditions: Transport on ice packs (blue ice).

Background

Haptoglobin is a liver‑derived glycoprotein that functions as a positive acute‑phase reactant, markedly up‑regulated during inflammation. It binds free hemoglobin to form complexes that are cleared from circulation, thereby preventing renal damage and iron loss. Numerous studies have linked haptoglobin expression levels to hemolytic disorders, liver function, diabetic nephropathy, coronary artery disease, and various inflammatory conditions.

Specifications and Pricing

Specification	Price (CNY)	Lead Time
5 µg	588	In stock (next‑day shipping)
20 µg	1498	In stock (next‑day shipping)
100 µg	5698	In stock (next‑day shipping)
1 mg	Please inquire	Please inquire

Note: This product is for research use only and is not intended for human or clinical diagnostic applications.

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Note: The above information may change due to product optimization or upgrades. For the most current details, please contact Yakoin Co.

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