Ultra-LEAF™ Purified anti-mous

Clone

MIB-5E9.1

Regulatory Status RUO

Other Names Interferon-β, Fibroblast interferon (Fi-IFN, F-IFN), Type-1 interferon, acid-stable interferon,

R1-G1 factor, IFN-b, IFN-beta

Isotype Armenian Hamster IgG

Description Interferon-β is a member of the type I interferon class. Type I IFNs are involved in the

innate immune system, being released non-specifically during the early stage of infection

in response to stimuli such as viruses, dsRNA, LPS, and bacterial components. Once

secreted by virus-infected or activated cells, they bind to the IFNα/β receptor (IFNAR),

which is found on almost all cell types, and, via the JAK-STAT pathway, induce the

expression of hundreds of IFN-stimulated genes (ISGs). While the function of many of

these proteins remains to be elucidated, a hallmark of type I IFNs is their anti-viral

activities, both general and specific against particular viruses. Type I IFNs also regulate

cell growth and apoptosis, and exert various immunomodulatory and inflammatory effects.

As such, they are also clinically relevant, both as therapeutics and as targets of inhibition

for the treatment of various autoimmune diseases and cancer.

Mouse IFN-β is a ~20 kD monomeric glycoprotein. It has 50% amino acid sequence

homology with mouse IFN-α, its closest related protein, and 62% homology with human

IFN-β. IFN-β is currently the therapeutic of choice for treating multiple sclerosis.