- 询价
- BIO-RAD
- MCA2245SBV515
- 2025年12月11日
- F
- Mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Purified murine platelets
- 亚型：
IgG1
- 形态：
Purified IgG conjugated to StarBright Violet 515 - liquid
- 克隆性：
Monoclonal Antibody
- 标记物：
StarBright Violet 515
- 适应物种：
Mouse
- 保质期：
自发货之日起 12 个月
- 目录编号：
MWReg30
- 供应商：
伯乐生命医学产品（上海）有限公司
- 应用范围：
F
- 浓度：
For information on the concentration of our StarBright Dye conjugated reagents please visit our FAQ page.
- 抗体名：
CD41 antibody | MWReg30
- 规格：
100 Tests/0.5ml
Rat anti Mouse CD41 antibody, clone MWReg30 recognizes the mouse integrin alpha IIb subunit CD41. CD41 is a ~125 kDa single pass type 1 transmembrane glycoprotein expressed by platelets, megakaryocytes (Zhang et al. 2007), mast cells (Berlanga et al. 2005), and hematopoietic progenitors (Mitjavila-Garcia et al. 2002). CD41 forms a heterodimer with CD61.
The CD41/CD61 complex is important for platelet adhesion and aggregation (Patel et al. 2003) acting as a receptor for many extracellular matrix proteins including fibronectin, thrombospondin and vitronectin (Weisel et al. 1992).
Rat anti mouse CD41, clone MWReg30 has been reported to inhibit PMA induced aggregation in vitro and to induce hypothermia in vivo (Nieswandt et al. 1999).
The CD41/CD61 complex is important for platelet adhesion and aggregation (Patel et al. 2003) acting as a receptor for many extracellular matrix proteins including fibronectin, thrombospondin and vitronectin (Weisel et al. 1992).
Rat anti mouse CD41, clone MWReg30 has been reported to inhibit PMA induced aggregation in vitro and to induce hypothermia in vivo (Nieswandt et al. 1999).
储存信息
This product is shipped at ambient temperature.
Store at +4°C. DO NOT FREEZE.
This product should be stored undiluted.
Store at +4°C. DO NOT FREEZE.
This product should be stored undiluted.
应用
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry | ✓ | Neat |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Flow Cytometry
Use 5μl of the suggested working dilution to label 106 cells in 100μl. Best practices suggest a 5 minutes centrifugation at 6,000g prior to sample application.
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文献和实验该产品被引用文献
Source Reference
- Nieswandt, B. et al. (1999) Acute systemic reaction and lung alterations induced by an antiplatelet integrin gpIIb/IIIa antibody in mice.
Blood. 94 (2): 684-93.
References for CD41 antibody
- Larson, M.K. and Watson, S.P. (2006) Regulation of proplatelet formation and platelet release by integrin alpha IIb beta3.
Blood. 108: 1509-14. - Tamagawa-Mineoka, R. et al. (2007) The role of platelets in leukocyte recruitment in chronic contact hypersensitivity induced by repeated elicitation.
Am J Pathol. 170: 2019-29. - Lutskiy, M.I. et al. (2007) WASP localizes to the membrane skeleton of platelets.
Br J Haematol. 139: 98-105. - Perez, L.E. et al. (2008) SH2-inositol phosphatase 1 negatively influences early megakaryocyte progenitors.
PLoS One. 3: e3565. - Zanzinger, K. et al. (2009) Regulation of triggering receptor expressed on myeloid cells 1 expression on mouse inflammatory monocytes.
Immunology. 128: 185-95. - Winter, O. et al. (2010) Megakaryocytes constitute a functional component of a plasma cell niche in the bone marrow.
Blood. 116: 1867-75. - Takayama, M. et al. (2010) Genetic analysis of hierarchical regulation for Gata1 and NF-E2 p45 gene expression in megakaryopoiesis.
Mol Cell Biol. 30: 2668-80. - Sullivan, B.P. et al. (2010) Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategies.
Toxicol Sci. 115: 286-94.
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Rat anti Mouse CD41:StarBright Violet 515
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