- 询价
- Miltenyi Biotec
- 德国
- 130-133-167
- 2025年12月09日
- MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- cell line
- human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Cyclin E1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，4-8℃
- 克隆性：
REAL1136
- 标记物：
Vio R667
- 适应物种：
human
- 保质期：
24个月
- 供应商：
Miltenyi biotec
- 宿主：
cell line
- 应用范围：
MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- 抗体英文名：
Cyclin E1 Antibody, anti-human, REAdye_lease™
- 抗体名：
Cyclin E1 Antibody, anti-human, REAdye_lease™
- 规格：
200 µL
Detection of Cyclin E1+ cellsClone REAL1136 is an antibody fragment derived from the full Cyclin E1 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity. | Clone REAL1136 recognizes the Cyclin E1, also known as CCNE1, that is a member of the highly conserved cyclin family. Cyclins are regulators of CDKs (Cyclin-dependent kinases). In a protein complex it functions as a regulatory subunit of CDK2, that is essential for the control of the cell cycle at the G1/S (start) transition. Cyclin E1 is present in testis and placenta and weakly expressed on bronchial epithelial cells. Mutations leads to overexpression of this gene and have been observed in many tumors. | For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675). |
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文献和实验该产品被引用文献
Koff, A. et al. (1992) Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. Science 257 (5077): 1689–1694. | Ohtsubo, M. et al. (1995) Human cyclin E, a nuclear protein essential for the G1-to-S phase transition. Mol. Cell. Biol. 15 (5): 2612–2624. | Nakayama, K. et al. (2016) CCNE1 amplification is associated with aggressive potential in endometrioid endometrial carcinomas. Int. J. Oncol. 48 (2): 506–516. | Turner, N. C. et al. (2019) Cyclin E1 Expression and Palbociclib Efficacy in Previously Treated Hormone Receptor-Positive Metastatic Breast Cancer. J. Clin. Oncol. 37 (14): 1169–1178.
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Cyclin E1 Antibody, anti-human, Vio® R667, REAdye_lease™, 200 µL
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