- 询价
- Miltenyi Biotec
- 德国
- 130-132-857
- 2025年12月09日
- MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- cell line
- human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
CD284 (TLR4)
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，4-8℃
- 克隆性：
REAL1458
- 标记物：
Vio B515
- 适应物种：
human
- 保质期：
24个月
- 供应商：
Miltenyi biotec
- 宿主：
cell line
- 应用范围：
MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- 抗体英文名：
CD284 (TLR4) Antibody, anti-human, REAdye_lease™
- 抗体名：
CD284 (TLR4) Antibody, anti-human, REAdye_lease™
- 规格：
200 µL
Detection of CD284 (TLR4)+ cellsClone REAL1458 is an antibody fragment derived from the full CD284 (TLR4) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity. | Clone REAL1458 recognizes the human CD284 (TLR4) antigen, a type I transmembrane signaling receptor also known as Toll-like receptor 4. Toll-like receptors are a family of pattern recognition receptors detecting the presence and characteristics of an infection and induce appropriately tailored innate and adaptive immune responses. TLR4 associates with its co-receptor MD-2. Together with the lipopolysaccharide (LPS)-binding protein (LBP) and CD14, this complex is responsible for signaling upon LPS recognition. CD284 (TLR4) is expressed on monocytes and myeloid dendritic cells. Low levels are expressed on B cells and granulocytes in human peripheral blood. HTA125 is able to block LPS-induced signaling and recognizes predominantly human TLR4 associated with MD-2. | For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675). |
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文献和实验该产品被引用文献
Shimazu, R. et al. (1999) MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J. Exp. Med. 189: 1777–1782. | Kawahara, T. et al. (2001) Type I Helicobacter pylori lipopolysaccharide stimulates Toll-like receptor 4 and activates mitogen oxidase 1 in gastric pit cells. Infect. Immun. 69: 4382–4389. | Wang, J. et al. (2001) Involvement of CD14 and Toll-Like receptors in activation of human monocytes by Aspergillus fumigatus hyphae. Infect. Immun. 69: 2402–2406. | Burgener, I. et al. (2008) Antibodies specific for human or murine Toll-like receptors detect canine leukocytes by flow cytometry. Vet Immunol Immunopathol 124: 184–191. | Jin, M. S. and Lee, J-O. (2008) Structures of the toll-like receptor family and its ligand complexes. Immunity 29: 182–191.
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CD284 (TLR4) Antibody, anti-human, Vio® B515, REAdye_lease™, 200 µL
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