- 询价
- Miltenyi Biotec
- 德国
- 130-130-617
- 2025年12月09日
- MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- cell line
- human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
53BP1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，4-8℃
- 克隆性：
REAL1211
- 标记物：
PE
- 适应物种：
human
- 保质期：
24个月
- 供应商：
Miltenyi biotec
- 宿主：
cell line
- 应用范围：
MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- 抗体英文名：
53BP1 Antibody, anti-human, REAdye_lease™
- 抗体名：
53BP1 Antibody, anti-human, REAdye_lease™
- 规格：
200 µL
Detection of 53BP1+ cellsClone REAL1211 is an antibody fragment derived from the full 53BP1 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity. | Clone REAL1211 recognizes the human 53BP1 (tumor protein p53 binding protein 1), a Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. It promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1. | For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675). |
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文献和实验该产品被引用文献
Lottersberger, F. et al. (2013) Role of 53BP1 oligomerization in regulating double-strand break repair. Proc. Natl. Acad. Sci. U.S.A. 110 (6): 2146–2151. | Callen, E. et al. (2013) 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell 153 (6): 1266–1280. | Noordermeer, S. M. et al. (2018) The shieldin complex mediates 53BP1-dependent DNA repair. Nature 560 (7716): 117–121.
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文献支持
53BP1 Antibody, anti-human, PE, REAdye_lease™, 200 µL
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