CD138 (Syndecan-1) Antibody, a

Identification and enumeration of CD138+ cells by flow cytometryClone REAL202 is an antibody fragment derived from the full CD138 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity | Clone REAL202 recognizes CD138, also known as syndecan-1, is a type I integral membrane protein belonging to the syndecan protein family which carries three to five heparan sulfate and chondroitin sulfate chains. CD138 is highly expressed on plasma cells and pre–B cells but not on mature peripheral B cells. It is also expressed on fibroblasts and epithelial cells. The expression of CD138 can be regulated by several cytokines and factors, e.g., thrombin, which is reported to increase the synthesis of CD138 molecules that exhibit high-affinity antithrombin-3 binding. | The REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes. |