- 询价
- Miltenyi Biotec
- 德国
- 130-125-009
- 2025年12月09日
- Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- cell line
- human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Podoplanin
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，4-8℃
- 克隆性：
REAL468
- 标记物：
FITC
- 适应物种：
human
- 保质期：
24个月
- 供应商：
Miltenyi biotec
- 宿主：
cell line
- 应用范围：
Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- 浓度：
1:50
- 抗体英文名：
Podoplanin Antibody, anti-human, REAlease®
- 抗体名：
Podoplanin Antibody, anti-human, REAlease®
- 规格：
100 tests in 200 µL
Identification and enumeration of Podoplanin+ cells by flow cytometryClone REAL468 is an antibody fragment derived from the full Podoplanin antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity. | Clone REAL468 recognizes the human Podoplanin antigen, a 38 to 44 kDa mucin-type transmembrane protein which is also known as E11, gp38, OTS-8, PA2.26, T1-alpha or Aggrus. Podoplanin has a wide variety of functions including regulation of organ development, cell motility, tumorigenesis and metastasis. It is expressed in multiple tissues during ontogeny and in adult, including the brain, heart, kidney, lungs, osteoblasts, and lymphoid organs. In lymphoid organs it is present in spleen 4 days postnatally. In adult, expression is detected on fibroblastic reticular cells, lymphatic endothelial cells, follicular dendritic cells in lymph node and spleen, and thymic medullary epithelial cells. Tumor cells often upregulate Podoplanin as they undergo epithelial-mesenchymal transition and this upregulation is correlated with increased motility and metastasis. | REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes.
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文献和实验该产品被引用文献
Herzog, B. H. et al. (2013) Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature 502 (7469): 105–109. | Zimmer, G. et al. (1999) Cloning and characterization of gp36, a human mucin-type glycoprotein preferentially expressed in vascular endothelium. Biochem. J. 341 (Pt 2): 277–284. | Bieniasz-Krzywiec, P. et al. (2019) Podoplanin-Expressing Macrophages Promote Lymphangiogenesis and Lymphoinvasion in Breast Cancer. Cell Metab. 30 (5): 917–936. | Astarita, J. L. et al. (2012) Expression of tumor necrosis factor receptor 2 characterizes TLR9-driven formation of interleukin-10-producing B cells. Front Immunol 12 (3): 283.
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Podoplanin Antibody, anti-human, FITC, REAlease®, 100 tests in 200 µL
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