CD106 (VCAM-1) Antibody, anti-

Detection of CD106 (VCAM-1)+ cellsClone REAL1098 is an antibody fragment derived from the full CD106 (VCAM-1) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity. | Clone REA1098 recognizes the mouse CD106 antigen, a 110 kDa single chain type I glycoprotein, also known as vascular cell adhesion protein 1 (VCAM-1). CD106 is expressed on bone marrow, stromal cells and inflamed vascular endothelium as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Upregulation of CD106 in endothelial cells by inflammatory stimuli and cytokines occurs as a result of increased gene transcription. Primarily, CD106 is an endothelial ligand for very late antigen-4 (VLA-4) or integrin α-4/β-7 and mediates both adhesion and signal transduction. The interactions play a pathophysiologic role in leukocyte adhesion, transmigration, and co-stimulation of T cell proliferation. | The REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes.