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CD52 Antibody, anti-human, APC

, REAfinity™, 100 tests in 200 µL
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  • 询价
  • Miltenyi Biotec已认证
  • 德国
  • 130-123-821
  • 2025年12月09日
  • Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
  • human cell line
  • human
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 免疫原

      CD52

    • 亚型

      recombinant human IgG1

    • 形态

      Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.

    • 保存条件

      避光,4-8℃

    • 克隆性

      REA164

    • 标记物

      APC

    • 适应物种

      human

    • 保质期

      24个月

    • 供应商

      Miltenyi biotec

    • 宿主

      human cell line

    • 应用范围

      Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry

    • 浓度

      1:50

    • 抗体英文名

      CD52 Antibody, anti-human, REAfinity™

    • 抗体名

      CD52 Antibody, anti-human, REAfinity™

    • 规格

      100 tests in 200 µL

    Identification and enumeration of CD52+ cells by flow cytometryClone REA164 recognizes CD52, a glycosylphosphatidylinositol (GPI)-anchored, 25–29 kDa heavily glycosylated antigen. The CD52 core peptide is only 12 amino acids long and is linked to the surface via C-terminal GPI anchor. Expression of CD52 is found on lymphocytes, monocytes, macrophages, eosinophils, and in the male reproductive tract on the epithelial cells of the epididymis and seminal vesicle. CD52 is absent in immature spermatozoa in the efferent ducts but is acquired by the sperm membrane, progressively, as they pass through the epididymis proper, where CD52 is shed into the seminal plasma by the epididymis. Though the exact role of CD52 is unclear, antibodies against CD52 elicit antibody dependent cellular and complement mediated cytolysis of the CD52 expressing lymphocytes. Owing to this, such antibodies are often used to target malignant cells. CD52 expressed on sperms and on lymphocytes are basically different glycoforms of the same core peptide. | Additional information: Clone REA164 displays negligible binding to Fc receptors. |

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    图标文献和实验
    该产品被引用文献
    Ambrose, L. R. et al. (2009) Neutrophils express CD52 and exhibit complement-mediated lysis in the presence of alemtuzumab. Blood 114: 3052–3055. | Rawstron, A. C. et al. (2006) CD52 expression patterns in myeloma and the applicability of alemtuzumab therapy. Haematologica 91: 1577 –1578. | Yeung, C. H. et al. (1998) Epididymal secretion of CD52 as measured in human seminal plasma by a fluorescence immunoassay. Mol. Hum. Reprod. 4: 447–451.
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    • AbC Anti-Mouse Bead Kit

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    • AbC Anti-Rat/Hamster Bead Kit

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    CD52 Antibody, anti-human, APC, REAfinity™, 100 tests in 200 µL
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