CD39 Antibody, anti-human, PE-Vio® 770, REAfinity™, 30 tests in 60 µL产品图
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CD39 Antibody, anti-human, PE-

Vio® 770, REAfinity™, 30 tests in 60 µL
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  • 询价
  • Miltenyi Biotec已认证
  • 德国
  • 130-110-790
  • 2025年12月09日
  • Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
  • human cell line
  • human
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 免疫原:

      CD39

    • 亚型:

      recombinant human IgG1

    • 形态:

      Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.

    • 保存条件:

      避光,4-8℃

    • 克隆性:

      REA739

    • 标记物:

      PE-Vio 770

    • 适应物种:

      human

    • 保质期:

      24个月

    • 供应商:

      Miltenyi Biotec

    • 宿主:

      human cell line

    • 应用范围:

      Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry

    • 浓度:

      1:50

    • 抗体英文名:

      CD39 Antibody, anti-human, REAfinity™

    • 抗体名:

      CD39 Antibody, anti-human, REAfinity™

    • 规格:

      30 tests in 60 µL

    Identification and enumeration of CD39+ cells by flow cytometryClone REA739 recognizes the 70–100 kDa membrane-bound human CD39 molecule, which is expressed on an effector/memory-like subset of FoxP3+ regulatory T cells. CD39 is an ectonucleotidase and catalyzes the hydrolysis of extracellular nucleotides, for example, ATP. Together with CD73, which is an ecto-5’-nucleotidase, this can lead to the production of adenosine. High extracellular ATP concentrations indicate tissue injury and cell death and induce various pro-inflammatory responses in immune cells. | Through its enzymatic activity, CD39 can contribute to the suppressive function of regulatory T cells, for example, by eliminating extracellular ATP or by generating adenosine, which has suppressive effects on various immune cells. | Additional information: Clone REA739 displays negligible binding to Fc receptors.

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    图标文献和实验
    该产品被引用文献
    Maliszewski, C. R. et al. (1994) The CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization. J Immunol 153 (8): 3574–3583. | Kaczmarek, E. et al. (1996) Identification and characterization of CD39/vascular ATP diphosphohydrolase. J. Biol. Chem. 271 (51): 33116–33122. | Borsellino, G. et al. (2007) Expression of ectonucleotidase CD39 by FoxP3+ reg cells: hydrolysis of extracellular ATP and immune suppression. Blood 110: 1225–1232.
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    CD39 Antibody, anti-human, PE-Vio® 770, REAfinity™, 30 tests in 60 µL
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