- 询价
- Miltenyi Biotec
- 德国
- 130-124-451
- 2025年12月09日
- Flow cytometry, Mass cytometry
- human cell line
- human, non-human primate
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
CD366 (TIM-3)
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，4-8℃
- 克隆性：
REA635
- 标记物：
Vio Bright FITC
- 适应物种：
human, non-human primate
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry, Mass cytometry
- 浓度：
1:50
- 抗体英文名：
CD366 (TIM-3) Antibody, anti-human, REAfinity™
- 抗体名：
CD366 (TIM-3) Antibody, anti-human, REAfinity™
- 规格：
30 tests in 60 µL
Identification and enumeration of CD366 (TIM-3)+ cells by flow cytometryClone REA635 recognizes the human CD366 antigen, a single-pass type I membrane protein, which is also known as T cell immunoglobulin and mucin domain containing protein-3 (TIM-3) or Hepatitis A virus cellular receptor 2 (HAVcr-2). CD366 is expressed on activated T cells, especially Tʜ1 cells, monocytes, macrophages, and dendritic cells. It is an activation-induced inhibitory molecule involved in tolerance and shown to induce T cell exhaustion in chronic viral infection and cancers. CD366 has been proposed to inhibit Tʜ1-mediated immune responses and regulates Tʜ1 and Tʜ17 cytokine secretion. The interaction of CD366 and its ligand galectin-9 induces apoptosis of Tʜ1 cells. | Additional information: Clone REA635 displays negligible binding to Fc receptors.
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文献和实验该产品被引用文献
Monney, L. et al. (2002) Tʜ1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 415: 536–541. | Zhu, C. et al. (2005) The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol 6 (12): 1245–1252. | Hastings, W. D. et al. (2009) TIM-3 is expressed on activated human CD4+ T cells and regulates Tʜ1 and Tʜ17 cytokines. Eur. J. Immunol. 39 (9): 2492–2501.
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CD366 (TIM-3) Antibody, anti-human, Vio® Bright FITC, REAfinity™, 30 tests in 60 µL
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