- 询价
- Miltenyi Biotec
- 德国
- 130-115-334
- 2025年12月09日
- Flow cytometry
- human cell line
- human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
CD338 (ABCG2)
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，4-8℃
- 克隆性：
REA909
- 标记物：
PE-Vio 615
- 适应物种：
human
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry
- 浓度：
1:50
- 抗体英文名：
CD338 (ABCG2) Antibody, anti-human, REAfinity™
- 抗体名：
CD338 (ABCG2) Antibody, anti-human, REAfinity™
- 规格：
30 tests in 60 µL
Identification and enumeration of CD338 (ABCG2)+ cells by flow cytometryClone REA909 recognizes the human CD338 antigen, a multi-pass membrane protein which is also known as ATP-binding cassette sub-family G member 2 (ABCG2) or breast cancer resistance protein (BCRP). CD338 is a member of the ATP-binding cassette (ABC) transporter superfamily and known to contribute to multidrug resistance in cancer chemotherapy. It is highly expressed on primitive stem cells as identified by the side-population phenotype, which is characterized by the efflux of chemicals, including the fluorescent dye Hoechst 33342 and Rhodamine 123. Among ABC transporters that are known to cause multidrug resistance, CD338 is particularly interesting for its potential role in protecting cancer stem cells and its complex oligomeric structure. | Additional information: Clone REA909 displays negligible binding to Fc receptors.
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文献和实验该产品被引用文献
Allikmets, R. et al. (1998) A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multi drug resistance. Cancer Res. 58 (23): 5337–5339. | Zhou, S. et al. (2001) The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nat Med 7 (9): 1028–1034. | Mo, W. et al. (2012) Human ABCG2: structure, function, and its role in multi drug resistance. Int J Biochem Mol Biol 3 (1): 1–27.
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CD338 (ABCG2) Antibody, anti-human, PE-Vio® 615, REAfinity™, 30 tests in 60 µL
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