- 询价
- Miltenyi Biotec
- 德国
- 130-109-519
- 2025年12月09日
- Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry, Mass cytometry
- human cell line
- human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
CD28
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，4-8℃
- 克隆性：
REA612
- 标记物：
Biotin
- 适应物种：
human
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry, Mass cytometry
- 浓度：
1:11
- 抗体英文名：
CD28 Antibody, anti-human, REAfinity™
- 抗体名：
CD28 Antibody, anti-human, REAfinity™
- 规格：
30 tests in 300 µL
Detection of CD28 on human or non-human primate leukocytesClone REA612 recognizes the human CD28 antigen, a type I transmembrane protein, which is highly expressed on CD3+ thymocytes, most peripheral thymocytes, and plasma cells but not in less mature B cells. Binding of CD28 to its ligands CD80 or CD86 costimulates T cell effector function and T cell–dependent antibody production in vitro and in vivo. In the presence of antibodies directed against CD2 and CD3, CD28 antibodies stimulate T cell proliferation and cytokine production. | Additional information: Clone REA612 displays negligible binding to Fc receptors.
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文献和实验该产品被引用文献
Kozbor D. J. et al. (1987) Tp44 molecules involved in antigen-independent T cell activation are expressed on human plasma cells. J Immunol 138 (12): 4128–4132. | Bahlis, N. J. et al. (2007) CD28-mediated regulation of multiple myeloma cell proliferation and survival. Blood 109 (11): 5002–5010. | Krummel, M. F. and Allison, J. P. (1995) CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182 (2): 459–465. | Freeman, G. J. et al. (1993) Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation. Science 262 (5135): 909–911. | Linsley, P. S. et al. (1993) The role of the CD28 receptor during T cell responses to antigen. Annu. Rev. Immunol. 11: 191–212. | June, C. H. et al. (1990) Role of the CD28 receptor in T-cell activation. Immunol. Today 11 (6): 211–216.
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CD28 Antibody, anti-human, Biotin, REAfinity™, 30 tests in 300 µL
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