- 询价
- Miltenyi Biotec
- 德国
- 130-122-819
- 2025年12月09日
- Flow cytometry, 3D-Immunofluorescence, Immunofluorescence, Immunohistochemistry
- human cell line
- human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
CD274 (B7-H1)
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，4-8℃
- 克隆性：
REA1197
- 标记物：
Vio Bright B515
- 适应物种：
human
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry, 3D-Immunofluorescence, Immunofluorescence, Immunohistochemistry
- 浓度：
1:50
- 抗体英文名：
CD274 (B7-H1) Antibody, anti-human, REAfinity™
- 抗体名：
CD274 (B7-H1) Antibody, anti-human, REAfinity™
- 规格：
30 tests in 60 µL
Identification and enumeration of CD274 (B7-H1)+ cells by flow cytometryClone REA1197 recognizes the human CD274 antigen, also known as programmed cell death 1 ligand 1 (PD-L1), an immune inhibitory receptor ligand which is involved in the costimulatory signal, essential for T cell proliferation and production of interleukin 10 (IL-10) and interferon γ (IFN-γ). | CD274 is expressed on activated T cells, B cells, dendritic cells (DCs), antigen-presenting cells, keratinocytes, monocytes, and various types of tumor cells. In tissues, CD274 is highly expressed in the heart, skeletal muscle, placenta, and lung and weakly expressed in the thymus, spleen, kidney, and liver. | PD-L1 is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. | Additional information: Clone REA1197 displays negligible binding to Fc receptors.
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文献和实验该产品被引用文献
Freeman, G. J. et al. (2000) Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 192 (7): 1027–1034. | Youngnak, P. et al. (2003) Differential binding properties of B7-H1 and B7-DC to programmed death-1. Biochem. Biophys. Res. Commun. 307 (3): 672–677. | Ahmed, M. et al. (2017) The too many faces of PD-L1: a comprehensive conformational analysis study. Biochemistry 56 (40): 5428–5439.
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文献支持
CD274 (B7-H1) Antibody, anti-human, Vio® Bright B515, REAfinity™, 30 tests in 60 µL
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