- 询价
- Miltenyi Biotec
- 德国
- 130-131-145
- 2025年12月09日
- 3D-Immunofluorescence, MICS (MACSima Imaging Cyclic Staining), 3D-Immunofluorescence, Immunofluorescence, Immunohistochemistry
- human cell line
- human, non-human primate
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
CD279 (PD1)
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，4-8℃
- 克隆性：
REA1165
- 标记物：
Vio R667
- 适应物种：
human, non-human primate
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
3D-Immunofluorescence, MICS (MACSima Imaging Cyclic Staining), 3D-Immunofluorescence, Immunofluorescence, Immunohistochemistry
- 浓度：
1:50
- 抗体英文名：
CD279 (PD1) Antibody, anti-human, REAfinity™
- 抗体名：
CD279 (PD1) Antibody, anti-human, REAfinity™
- 规格：
600 µL
Detection of CD279 (PD1)+ cellsClone REA1165 recognizes the human CD279 antigen, also known as programmed death-1 (PD-1) or PD1. CD279 is a 55 kDa transmembran protein belonging to the CD28/CTLA-4 family. It is expressed on T cells, B cells, NK cells, activated myeloid cells, and dendritic cells. CD279 is not expressed on naive T cells but induced after activation and expressed on late, differentiated T cells. The ligands PD-L1 (CD274, also knwon as B7-H1) and PD-L2 (CD273, also known as B7-DC) belong to the B7 immunglobulin superfamily. PD-1 and its ligands mediate inhibitory signals that regulate the balance between T cell activation, tolerance, and immunopathology. | Additional information: Clone REA1165 displays negligible binding to Fc receptors.
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文献和实验该产品被引用文献
Okazaki, T. and Honjo, T. (2007) PD-1 and PD-1 ligands: from discovery to clinical application. Int. Immunol. 19: 813–824. | Keir, M. E. et al. (2008) PD-1 and its ligands in tolerance and immunity. Annu. Rev. Immunol. 26: 677–704. | Serriari, N.-E. et al. (2010) B and T lymphocyte attenuator is highly expressed on CMV-specific T cells during infection and regulates their function. J Immunol 185: 3140–3148. | Fife, B. T. et al. (2011) The role of the PD-1 pathway in autoimmunity and peripheral tolerance. Ann. N. Y. Acad. Sci. 1217: 45–59.
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CD279 (PD1) Antibody, anti-human, Vio® R667, REAfinity™, 600 µL
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