- 询价
- Miltenyi Biotec
- 德国
- 130-118-970
- 2025年12月09日
- Flow cytometry
- human cell line
- human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
CD269 (BCMA)
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，4-8℃
- 克隆性：
REA315
- 标记物：
PE
- 适应物种：
human
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry
- 浓度：
1:50
- 抗体英文名：
CD269 (BCMA) Antibody, anti-human, REAfinity™
- 抗体名：
CD269 (BCMA) Antibody, anti-human, REAfinity™
- 规格：
100 tests in 200 µL
Identification and enumeration of CD269 (BCMA)+ cells by flow cytometryClone REA315 recognizes the human CD269 antigen, a single-pass type III membrane protein which is also known as B cell maturation antigen (BCMA). CD269 is a member of the TNF-receptor superfamily that is preferentially expressed in mature B lymphocytes. It is the receptor for CD256 (TNFSF13, APRIL) and CD257 (TNFSF13B, BLyS, BAFF). CD269 promotes B cell survival and plays a role in the regulation of humoral immunity. Binding of CD269 to CD257 blocks the binding of CD257 to its receptor on the plasma membrane and inhibits CD257-triggered B lymphocyte costimulation. Overexpression of CD269 activates NF-κB and JNK, and this activation is potentiated by CD257. | Additional information: Clone REA315 displays negligible binding to Fc receptors. |
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文献和实验该产品被引用文献
Yu, G. et al. (2000) APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity. Nat Immunol 1 (3): 252–256. | Shu, H. B. et al. (2000) B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1. Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9156–9161. | Laabi, Y. et al. (1994) The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed. Nucleic Acids Res. 22 (7): 1147–1154.
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CD269 (BCMA) Antibody, anti-human, PE, REAfinity™, 100 tests in 200 µL
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