CD267 (TACI) Antibody, anti-hu

Identification and enumeration of CD267 (TACI)+ cells by flow cytometryClone REA1229 recognizes the human CD267 antigen, a 32 kDa type III transmembrane protein belonging to the TNF receptor superfamily. CD267 as receptor binds to BAFF and APRIL and plays an important role in the stimulation of B- and T-cell function and in the regulation of humoral immunity. CD267 expression is found in CD27+ memory B cells, tonsillar and bone marrow plasma cells, in a subpopulation of activated CD27-, non GC cells and in a small subset of naïve blood and tonsil B cells. CD267 is also expressed on many lymphomas such as multiple myeloma and Hodgkin and non-Hodgkin lymphomas. Mutations in CD267 are often associated with common variable immunodeficiency in humans. Signaling via CD267 leads to activation of the transcription factors NFAT, AP1, and NF-kappa-B. | Additional information: Clone REA1229 displays negligible binding to Fc receptors.