- 询价
- Miltenyi Biotec
- 德国
- 130-106-039
- 2025年12月09日
- Flow cytometry
- human cell line
- mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
CD244.2
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，4-8℃
- 克隆性：
REA388
- 标记物：
PE-Vio 770
- 适应物种：
mouse
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry
- 浓度：
1:10
- 抗体英文名：
CD244.2 Antibody, anti-mouse, REAfinity™
- 抗体名：
CD244.2 Antibody, anti-mouse, REAfinity™
- 规格：
9 µg in 300 µL
Identification and enumeration of CD244.2+ cells by flow cytometryClone REA388 recognizes an alloantigen of the mouse CD244 antigen, a Single-pass type I membrane protein also known as 2B4. CD244 is a receptor belonging to the CD2 subfamily of the Ig superfamily and is involved in non-MHC dependent cytotoxicity. Expression of CD244 is found on all NK cells, γδ T cells, basophils, and monocytes as well as a subset of memory-phenotype CD8+ αβ T cells. The ligand of CD244 is CD48, which is expressed on all hematopoietic cells. CD244 is primarily involved in inhibiting NK cell functions. In inbred mice, at least two splice variants exist that differ in the length of the cytoplasmic domain. The long form functions in an inhibitory manner, while the short form functions in an activating manner. Clone REA388 reacts with CD244.2, the CD244 allloantigen which is expressed on C57BL/6 and C58/J mice, but not in Balb/c mice. | Additional information: Clone REA388 displays negligible binding to Fc receptors.
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文献和实验该产品被引用文献
Mathew, P. A. et al. (1993) Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells. J Immunol 151 (10): 5328–5337. | Kumaresan, P. R. et al. (2000) Polymorphism in the 2B4 gene of inbred mouse strains. Immunogenetics 51 (8-9): 758–761. | McNerney, M. E. et al. (2005) 2B4 (CD244) is a non-MHC binding receptor with multiple functions on natural killer cells and CD8+ T cells. Mol. Immunol. 42 (4): 489 –494.
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CD244.2 Antibody, anti-mouse, PE-Vio® 770, REAfinity™, 9 µg in 300 µL
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