- 询价
- Miltenyi Biotec
- 德国
- 130-124-523
- 2025年12月09日
- Mass cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry, Mass cytometry
- human cell line
- human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
CD244 (2B4)
- 亚型：
recombinant human IgG1
- 形态：
Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
- 保存条件：
避光，4-8℃
- 克隆性：
REA112
- 标记物：
pure
- 适应物种：
human
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Mass cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry, Mass cytometry
- 抗体英文名：
CD244 (2B4) Antibody, anti-human, REAfinity™
- 抗体名：
CD244 (2B4) Antibody, anti-human, REAfinity™
- 规格：
100 µg in 100 µL
Identification and enumeration of CD244 (2B4)+ cells by mass cytometryClone REA112 recognizes CD244, a type I transmembrane receptor belonging to the CD2 subfamily of the Ig superfamily. Expression of CD244 is found on all natural killer (NK) cells, large subset of CD8+ T cells, a small fraction of CD4+ T cells, and eosinophils. Human CD244 upon ligand engagement activates NK cell cytotoxicity and production of interferon gamma (IFN-γ). Activating function of human CD244 requires recruitment of SH2 domain containing molecule called SLAM associated protein (SAP). In humans, CD244 has also been implicated as an inhibitory receptor such as in developing NK cells. In contrast, murine CD244 is primarily involved in inhibiting NK cell functions. Two isoforms of human CD244 exist on NK cells, h2B4-A and h2B4-B, which differ in their binding affinity to ligand CD48. | Additional information: Clone REA112 displays negligible binding to Fc receptors. |
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文献和实验该产品被引用文献
Munitz, A. et al. (2005) 2B4 (CD244) is expressed and functional on human eosinophils. J Immunol 174: 110–118. | Sivori, S. et al. (2002) Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation. Proc. Natl. Acad. Sci. U.S.A. 99: 4526–4531. | Mathew, S. O. et al. (2009) Functional role of human NK cell receptor 2B4 (CD244) isoforms. Eur. J. Immunol. 39 (6): 1632–1641. | Vaidya, S. V. et al. (2006) Of mice and men: different functions of the murine and human 2B4 (CD244) receptor on NK cells. Immunol. Lett. 105 (2): 180–184.
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CD244 (2B4) Antibody, anti-human, pure, REAfinity™, 100 µg in 100 µL
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