- 询价
- Miltenyi Biotec
- 德国
- 130-133-017
- 2025年12月09日
- Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- human cell line
- human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
CD243 (ABCB1)
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，4-8℃
- 克隆性：
REA495
- 标记物：
PE-Vio 615
- 适应物种：
human
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- 浓度：
1:50
- 抗体英文名：
CD243 (ABCB1) Antibody, anti-human, REAfinity™
- 抗体名：
CD243 (ABCB1) Antibody, anti-human, REAfinity™
- 规格：
100 tests in 200 µL
Identification and enumeration of CD243 (ABCB1)+ cells by flow cytometryClone REA495 recognizes the human CD243 antigen, a multi-pass membrane protein which is also known as multidrug resistance protein 1 (MDR1), ATP-binding cassette sub-family B member 1 (ABCB1), or P-glycoprotein 1. CD243 is a member of the ATP-binding cassette (ABC) transporter superfamily and plays an important role in the development of multidrug resistance (MDR) in cancer cells. This transporter utilizes energy from ATP hydrolysis for the efflux of a variety of chemically dissimilar amphipathic compounds, including anticancer drugs. CD243 is extensively distributed and expressed in the intestinal epithelium, in liver cells, in the cells of the proximal tubule of the kidney and in the capillary endothelial cells composing the blood-brain barrier and blood-testis barrier. It is also expressed on hematopoietic stem cells, T cells, B cells, and NK cells as well as on many multidrug resistant neoplastic cells. | Additional information: Clone REA495 displays negligible binding to Fc receptors.
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文献和实验该产品被引用文献
Chen, C. J. et al. (1986) Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. Cell 47 (7): 381–389. | Yao, W. et al. (2014) CD243 gene polymorphism significantly associated with breast cancer susceptibility. Tumour Biol 35 (8): 8017–8022. | Brambila-Tapia, A. J. (2013) MDR1 (ABCB1) polymorphisms: functional effects and clinical implications. Rev Invest Clin 65 (5): 445–454.
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CD243 (ABCB1) Antibody, anti-human, PE-Vio® 615, REAfinity™, 100 tests in 200 µL
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