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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
CD206
- 亚型:
recombinant human IgG1
- 形态:
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件:
避光,4-8℃
- 克隆性:
REA1207
- 标记物:
PE-Vio 670
- 适应物种:
human
- 保质期:
24个月
- 供应商:
Miltenyi Biotec
- 宿主:
human cell line
- 应用范围:
Flow cytometry
- 浓度:
1:50
- 抗体英文名:
CD206 Antibody, anti-human, REAfinity™
- 抗体名:
CD206 Antibody, anti-human, REAfinity™
- 规格:
100 tests in 200 µL
Identification and enumeration of CD206+ cells by flow cytometryClone REA1207 recognizes the human CD206 antigen, also known as Mannose receptor (MR) or macrophage MR, which is a 162–175 kDa type I membrane protein. It contains an N-terminal cystein-rich domain and eight C-type lectin-like domains (CTLDs), beside a transmembrane and a cytoplasmic domain. CD206 is expressed by macrophages, dendritic cells, and subsets of endothelial cells, but not on monocytes. The MR recognizes multiple mainly microbial carbohydrates with mannose, fucose, or N-acetyl glucosamine residues. The MR mediates endocytosis and phagocytosis, linked to antigen presentation. It plays an important role in host defense and provides a link between innate and adaptive immunity. | Additional information: Clone REA1207 displays negligible binding to Fc receptors.
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文献和实验该产品被引用文献
Wileman, T. E. et al. (1986) Identification of the macrophage mannose receptor as a 175-kDa membrane protein. Proc. Natl. Acad. Sci. U.S.A. 83: 2501–2505. | Lennartz, M. R. et al. (1989) Biosynthesis and processing of the mannose receptor in human macrophages. J. Biol. Chem. 264: 2385–2390. | Ezekowitz, R. A. B. et al. (1990) Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells. J. Exp. Med. 172: 1785–1794. | Sallusto, F. et al. (1995) Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartement: downregulation by cytokines and bacterial products. J. Exp. Med. 182: 389–400. | Feinberg, H. et al. (2000) Structure of a C-type carbohydrate recognition domain from the macrophage mannose receptor. J. Biol. Chem. 275: 21539–21548. | Kang, P. B. et al. (2005) The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis. J. Exp. Med. 202: 987–999. | Tacken, P. J. et al. (2005) Effective induction of naive and recall T-cell responses by targeting antigen to human dendritic cells via a humanized anti-DC-SIGN antibody. Blood 106: 1278–1285. | Ng, Y. S. (2012) Chemical transfection of dye-conjugated microRNA precursors for microRNA functional analysis of M2 macrophages. J. Cell. Biochem. 113 (5): 1714–1723.
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CD206 Antibody, anti-human, PE-Vio® 670, REAfinity™, 100 tests in 200 µL
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