- 询价
- Miltenyi Biotec
- 德国
- 130-118-754
- 2025年12月09日
- Flow cytometry
- human cell line
- human, non-human primate
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
CD205 (DEC205)
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，4-8℃
- 克隆性：
REA1080
- 标记物：
PE-Vio 615
- 适应物种：
human, non-human primate
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry
- 浓度：
1:50
- 抗体英文名：
CD205 (DEC205) Antibody, anti-human, REAfinity™
- 抗体名：
CD205 (DEC205) Antibody, anti-human, REAfinity™
- 规格：
30 tests in 60 µL
Identification and enumeration of CD205 (DEC205)+ cells by flow cytometryClone REA1080 recognizes the human CD205 (DEC205) antigen, a glycoprotein also known as Ly-75. CD205 is a 210 kDa C-type lectin single-pass membrane protein (type I), which is highly expressed on thymic epithelial cells and dendritic cells. Unlike murine CD205, human CD205 is also found at low levels on other peripheral blood lymphocytes, eg., monocytes, T cells, B cells, and NK cells. CD205 belongs to the macrophage mannose receptor family and acts as an endocytic receptor to uptake antigens, direct the captured antigens from the extracellular space to the antigen-processing compartment for antigen presentation on MHC class II and cross-presentation on MHC class I molecules. Another function of CD205 is the clearance of apoptotic cells, potentially an important pathway for the uptake of self-antigen in intrathymic and peripheral tolerance. | Additional information: Clone REA1080 displays negligible binding to Fc receptors.
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文献和实验该产品被引用文献
Guo, M. et al. (2000) A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells. Hum. Immunol. 61 (8): 729–738. | Bonifaz, L. et al. (2004) In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination. J. Exp. Med. 199: 815–824. | Heath, W. et al. (2004) Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens. Immunol. Rev. 199: 9–26. | Shrimpton, R. et al. (2009) CD205 (DEC-205): A recognition receptor for apoptotic and necrotic self. Mol. Immunol. 46 (6): 1229–1239.
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CD205 (DEC205) Antibody, anti-human, PE-Vio® 615, REAfinity™, 30 tests in 60 µL
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