- 询价
- Miltenyi Biotec
- 德国
- 130-120-459
- 2025年12月09日
- Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry, Mass cytometry
- human cell line
- human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
CD196 (CCR6)
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，4-8℃
- 克隆性：
REA190
- 标记物：
PE-Vio 615
- 适应物种：
human
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry, Mass cytometry
- 浓度：
1:50
- 抗体英文名：
CD196 (CCR6) Antibody, anti-human, REAfinity™
- 抗体名：
CD196 (CCR6) Antibody, anti-human, REAfinity™
- 规格：
100 tests in 200 µL
Identification and enumeration of CD196 (CCR6)+ cells by flow cytometryClone REA190 recognizes CD196 (CCR6), a seven transmembrane G protein–coupled receptor, which belongs to the family of beta chemokine receptors. Expression of CD196 is found on T cells, naive and memory B cells, and immature dendritic cells (DCs). CD196 selectivly binds chemokine MIP-3α/CCL20, which is secreted by a number of cells and tissues. In addition, members of a family of small cationic antimicrobial peptides, such as human β-defensins (hBD)-1 and -2, which are released by epithelial cells in response to microbial invasion or proinflammatory stimuli, are also shown to bind to CCR6. This interaction induce chemotaxis in immature dendritic cells and memory T cells. | Additional information: Clone REA190 displays negligible binding to Fc receptors. |
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文献和实验该产品被引用文献
Yang, D. et al. (1999) Beta-defensins: Linking innate and adaptive immunity through dendritic and T cell CCR6. Science 286 (5439): 525–528. | Bergmann-Leitner, E. et al. (2018) Identification of immune signatures of novel adjuvant formulations using machine learning. Sci Rep 8 (1): 17508. | Dorraji, E. et al. (2018) Mesenchymal stem cells and T cells in the formation of tertiary lymphoid structures in lupus nephritis. Sci Rep: 7861. | Farooq, F. et al. (2016) Circulating follicular T helper cells and cytokine profile in humans following vaccination with the rVSV-ZEBOV Ebola vaccine. Sci Rep 6: 27944. | Schutyser, E. et al. (2003) The CC chemokine CCL20 and its receptor CCR6. Cytokine Growth Factor Rev. 14 (5): 409–426. | Armas-González, E. et al. (2018) Role of CXCL13 and CCL20 in the recruitment of B cells to inflammatory foci in chronic arthritis. Arthritis Res. Ther. 20 (1): 114.
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CD196 (CCR6) Antibody, anti-human, PE-Vio® 615, REAfinity™, 100 tests in 200 µL
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