- 询价
- Miltenyi Biotec
- 德国
- 130-107-656
- 2025年12月09日
- Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- human cell line
- mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
CD185 (CXCR5)
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，4-8℃
- 克隆性：
REA215
- 标记物：
PE-Vio 615
- 适应物种：
mouse
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- 浓度：
1:10
- 抗体英文名：
CD185 (CXCR5) Antibody, anti-mouse, REAfinity™
- 抗体名：
CD185 (CXCR5) Antibody, anti-mouse, REAfinity™
- 规格：
9 µg in 300 µL
Identification and enumeration of CD185 (CXCR5)+ cells by flow cytometryClone REA215 recognizes murine CD185, which is a 42 kDa multipass chemokine receptor, also known as CXCR5 or burkitt lymphoma receptor-1 (BLR). Expression of CD185 is found on mature recirculating B cells, a small subset of CD4+ and CD8+ T cells, and skin-derived migratory dendritic cells. CXCR5 recognizes B cell–attracting chemokine 1 (BCA-1)/ CXCL13 as ligand, which is a homeostatic chemokine, constitutively secreted by stromal cells in B cell areas of secondary lymphoid tissues (follicles). CXCR5 is involved in recruitment of circulating naive B cells to follicles and trafficking and homing of B1 B cells. Mice lacking CXCR5 gene display defective primary follicles and germinal centers formation in the spleen and Peyer patches, and lack inguinal lymph nodes. | Additional information: Clone REA215 displays negligible binding to Fc receptors. |
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文献和实验该产品被引用文献
Junt, T. et al. (2005) CXCR5-dependent seeding of follicular niches by B and Th cells augments antiviral B cell responses. J Immunol 175: 7109–7116. | Velaga, S. et al. (2009) Chemokine receptor CXCR5 supports solitary intestinal lymphoid tissue formation, B cell homing, and induction of intestinal IgA responses. J Immunol 182: 2610–2619.
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文献支持
CD185 (CXCR5) Antibody, anti-mouse, PE-Vio® 615, REAfinity™, 9 µg in 300 µL
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