- 询价
- Miltenyi Biotec
- 德国
- 130-124-119
- 2025年12月09日
- Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- human cell line
- mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
CD18
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，4-8℃
- 克隆性：
REA1226
- 标记物：
PE
- 适应物种：
mouse
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- 浓度：
1:50
- 抗体英文名：
CD18 Antibody, anti-mouse, REAfinity™
- 抗体名：
CD18 Antibody, anti-mouse, REAfinity™
- 规格：
30 µg in 200 µL
Identification and enumeration of CD18+ cells by flow cytometryClone REA1226 recognizes the murine CD18 antigen, a 95 kDa glycoprotein also known as integrin beta-2 (ITGB2). CD18 associates non-covalently with CD11a, CD11b, and CD11c to form LFA-1, Mac-1, and gp150/95, respectively and plays an important role in leukocytes adhesion. It is expressed on all leukocytes with NK and T cells showing higher density of surface expression. The CD18 integrin complexes bind CD54 (ICAM-1), CD102 (ICAM-2), CD50 (ICAM-3), iC3b, and fibrinogen. Heterodimers of CD18 with α subunits show different expression patterns on different leucocytes. Mice leucocytes lacking CD18 or expressing dysfunctional CD18 are defective in chemotaxis, phagocytosis, and homotypic aggregation. | Additional information: Clone REA1226 displays negligible binding to Fc receptors.
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文献和实验该产品被引用文献
Wilson, R. W. et al. (1993) Gene targeting yields a CD18-mutant mouse for study of inflammation. J Immunol 151: 1571–1578. | Tan, S. M. (2012) The leucocyte β2 (CD18) integrins: the structure, functional regulation and signalling properties. Biosci. Rep. 32 (3): 241–269. | Jakus, Z. et al. (2007) Immunoreceptor-like signaling by β 2 and β 3 integrins. Trends Cell Biol. 17 (10): 493–501.
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CD18 Antibody, anti-mouse, PE, REAfinity™, 30 µg in 200 µL
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