- 询价
- Miltenyi Biotec
- 德国
- 130-120-923
- 2025年12月09日
- Flow cytometry
- human cell line
- mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
CD178
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，4-8℃
- 克隆性：
REA1171
- 标记物：
PE-Vio 615
- 适应物种：
mouse
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry
- 浓度：
1:50
- 抗体英文名：
CD178 Antibody, anti-mouse, REAfinity™
- 抗体名：
CD178 Antibody, anti-mouse, REAfinity™
- 规格：
150 µg in 1 mL
Identification and enumeration of CD178+ cells by flow cytometryClone REA1171 recognizes the type II transmembrane glycoprotein mouse CD178, also known as Fas Ligand, FasL, or CD95 Ligand, which is a 40 kDa member of the TNF cytokine family expressed on activated lymphocytes such as T cells, NK cells, or monocytes as well as in immune-privilaged sites, e.g, cornea or testis. CD178 can trigger apoptosis through trimerization of the Fas receptor CD95. Thereby, CD178 and CD95 play a key role in the regulation of the immune system. Cleavage of membrane bound CD178 from the cell surface via matrix metalloproteinases (such as MMP-7) generates soluble CD178 molecules. | Additional information: Clone REA1171 displays negligible binding to Fc receptors.
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文献和实验该产品被引用文献
Takahashi, T. et al. (1994) Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76 (6): 969–976. | Oyaizu, N. et al. (1997) Monocytes express Fas ligand upon CD4 cross-linking and induce CD4+ T cells apoptosis: a possible mechanism of bystander cell death in HIV infection. J Immunol 158: 2456 –2463. | Kayagaki, N. et al. (1997) Polymorphism of murine Fas ligand that affects the biological activity. Proc. Natl. Acad. Sci. U.S.A. 94: 3914 –3919. | Janssen, O. et al. (2003) CD95 ligand – death factor and costimulatory molecule? Cell Death Differ. 10 (11): 1215–1225.
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CD178 Antibody, anti-mouse, PE-Vio® 615, REAfinity™, 150 µg in 1 mL
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