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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
CD184 (CXCR4)
- 亚型:
recombinant human IgG1
- 形态:
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件:
避光,4-8℃
- 克隆性:
REA107
- 标记物:
Biotin
- 适应物种:
mouse
- 保质期:
24个月
- 供应商:
Miltenyi Biotec
- 宿主:
human cell line
- 应用范围:
Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- 浓度:
1:10
- 抗体英文名:
CD184 (CXCR4) Antibody, anti-mouse, REAfinity™
- 抗体名:
CD184 (CXCR4) Antibody, anti-mouse, REAfinity™
- 规格:
9 µg in 300 µL
Identification and enumeration of CD184 (CXCR4)+ cells by flow cytometryClone REA107 reacts with CD184, a receptor for C-X-C chemokine CXCL12/SDF-1. CD184 is a seven membrane spanning receptor and belongs to the family of G-protein coupled chemokine receptors. Expression of CD184 is found in tissues including spleen, thymus, bone marrow, lymph nodes, and at lower levels in small intestine, kidney, and stomach. Diverse functions of CD184 include promoting survival and proliferation of hematopoietic stem cells, inducing apoptosis in T cells, regulating osteoclastogenesis, B cell development, vascularization of the gastrointestinal tract, germ cell migration/survival, and cerebellar development. CD184 also serves as a co-receptor for entry into target cells by HIV-1 X4 and interacts with extracellular ubiquitin. | Additional information: Clone REA107 displays negligible binding to Fc receptors. |
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文献和实验该产品被引用文献
Drummond, R. A. et al. (2014) Cutting edge: Failure of antigen-specific CD4+ T cell recruitment to the kidney during systemic candidiasis. J Immunol 193 (11): 5381–5385. | Förster, R. et al. (1998) Intracellular and surface expression of the HIV-1 coreceptor CXCR4/Fusin on various leukocyte subsets: rapid internalization and recycling upon activation. J Immunol 160: 1522 –1531. | Tachibana, K. et al. (1998) The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature 393: 591–594. | Zou, Y.-R. et al. (1998) Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature 393: 595–599. | Wegner, S. A. et al. (1998) Genomic organization and functional characterization of the chemokine receptor CXCR4, a major entry co-receptor for human immunodeficiency virus type 1. J. Biol. Chem. 273 (8): 4754–4760.
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CD184 (CXCR4) Antibody, anti-mouse, Biotin, REAfinity™, 9 µg in 300 µL
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