- 询价
- Miltenyi Biotec
- 德国
- 130-107-712
- 2025年12月09日
- Flow cytometry
- human cell line
- rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
CD172a (SIRPα)
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，4-8℃
- 克隆性：
REA490
- 标记物：
PE
- 适应物种：
rat
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry
- 浓度：
1:10
- 抗体英文名：
CD172a (SIRPα) Antibody, anti-rat, REAfinity™
- 抗体名：
CD172a (SIRPα) Antibody, anti-rat, REAfinity™
- 规格：
30 µg in 1 mL
Identification and enumeration of CD172a (SIRPα)+ cells by flow cytometryClone REA490 recognizes the rat antigen CD172a, a 75–110 kDa glycosylated receptor-like protein, which is also known as SIRPα or SHPS-1. It binds to its ligand CD47, which inhibits cytokine production by mature dendritic cells (DCs) and avoids maturation of immature DCs. SHPS-1 plays a role in the negative regulation of receptor tyrosine kinase–coupled cellular responses induced by cell adhesion, growth factors, or insulin and mediates negative regulation of phagocytosis, mast cell, and DC activation. CD172a is expressed by neurons and myeloid cells, such as monocytes, macrophages, granulocytes, and DCs. | Additional information: Clone REA490 displays negligible binding to Fc receptors.
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文献和实验该产品被引用文献
Adams, S. et al. (1998) Signal-regulatory protein is selectively expressed by myeloid and neuronal cells. J Immunol 161: 1853–1859. | Takada, T. et al. (1998) Roles of the complex formation of SHPS-1 with SHP-2 in insulin-stimulated mitogen-activated protein kinase activation. J. Biol. Chem. 273 (15): 9234–9242. | Fujioka, Y. et al. (1996) A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion. Mol. Cell. Biol. 16 (12): 6887–6899.
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CD172a (SIRPα) Antibody, anti-rat, PE, REAfinity™, 30 µg in 1 mL
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