- 询价
- Miltenyi Biotec
- 德国
- 130-123-155
- 2025年12月09日
- Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- human cell line
- mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
CD172a (SIRPα)
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，4-8℃
- 克隆性：
REA1201
- 标记物：
APC-Vio 770
- 适应物种：
mouse
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- 浓度：
1:50
- 抗体英文名：
CD172a (SIRPα) Antibody, anti-mouse, REAfinity™
- 抗体名：
CD172a (SIRPα) Antibody, anti-mouse, REAfinity™
- 规格：
30 µg in 200 µL
Identification and enumeration of CD172a (SIRPα)+ cells by flow cytometryClone REA1201 recognizes the mouse antigen CD172a, a 75–110 kDa glycosylated receptor-like protein, which is also known as SIRPα or SHPS-1. CD172a promotes the attachment and neurite outgrowth of cultured murine cerebellar cells. It binds to its ligand CD47, which inhibits cytokine production by mature dendritic cells (DCs) and avoids maturation of immature DCs. CD172a plays a role in the negative regulation of receptor tyrosine kinase–coupled cellular responses induced by cell adhesion, growth factors, or insulin and mediates negative regulation of phagocytosis, mast cell, and DC activation. CD172a is strongly expressed by neurons and myeloid cells, such as monocytes, macrophages, granulocytes, and DCs in several tissues, e.g., cerebral cortex, brain, spinal cord, cerebellum, and spleen. CD172a is not expressed on oligodendrocytes or GFAP-positive astrocytes. | Additional information: Clone REA1201 displays negligible binding to Fc receptors.
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文献和实验该产品被引用文献
Chuang, W. et al. (1990) Central nervous system antigen P84 can serve as a substrate for neurite outgrowth. Dev. Biol. 137 (2): 219–232. | Comu, S. et al. (1997) The murine P84 neural adhesion molecule is SHPS-1, a member of the phosphatase-binding protein family. J. Neurosci. 17 (22): 8702–8710. | Qu, T. et al. (2022) Targeting CD47/SIRPalpha as a therapeutic strategy, where we are and where we are headed. Biomark Res 10 (1): 20 doi.
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文献支持
CD172a (SIRPα) Antibody, anti-mouse, APC-Vio® 770, REAfinity™, 30 µg in 200 µL
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