- 询价
- Miltenyi Biotec
- 德国
- 130-120-588
- 2025年12月09日
- Flow cytometry, Mass cytometry
- human cell line
- human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
CD159c (NKG2C)
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，4-8℃
- 克隆性：
REA205
- 标记物：
Biotin
- 适应物种：
human
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry, Mass cytometry
- 浓度：
1:50
- 抗体英文名：
CD159c (NKG2C) Antibody, anti-human, REAfinity™
- 抗体名：
CD159c (NKG2C) Antibody, anti-human, REAfinity™
- 规格：
30 tests in 60 µL
Identification and enumeration of CD159c (NKG2C)+ cells by flow cytometryClone REA205 recognizes the CD159c antigen, a calcium-dependent (C-type) lectin which is also known as NKG2C type II integral membrane protein or KLRC2. CD159c heterodimerizes with CD94 to form a complex that recognizes HLA-E as ligand. Clone REA205 detects the human CD159c/CD94 heterodimer and does not cross-react with the human CD159a/CD94 heterodimer or with the human CD94 homodimer. CD159c is expressed primarily on natural killer (NK) cells and receptor ligation results in NK cell activation. The proportion of CD3+ T cells expressing the CD159c/CD94 complex is elevated under pathologic conditions, such as human CMV infection, active celiac disease, paroxysmal nocturnal hemoglobinuria, Stevens-Johnson syndrome, and toxic epidermal necrolysis. | Additional information: Clone REA205 displays negligible binding to Fc receptors. |
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文献和实验该产品被引用文献
Houchins, J. P. et al. (1997) Natural killer cell cytolytic activity is inhibited by NKG2-A and activated by NKG2-C. J Immunol 158 (8): 3603–3609. | Zaguia, F. et al. (2013) Cytotoxic NKG2C+ CD4 T cells target oligodendrocytes in multiple sclerosis. J Immunol 190 (6): 2510–2518. | Houchins, J. P. et al. (1991) DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. J. Exp. Med. 173 (4): 1017–1020. | Kruse, V. et al. (2015) Human induced pluripotent stem cells are targets for allogeneic and autologous natural killer (NK) cells and killing is partly mediated by the activating NK receptor DNAM-1. PLoS One 10 (5): e0125544. | López-Botet, M. et al. (1997) The CD94/NKG2C-type lectin receptor complex in recognition of HLA class I molecules. Res. Immunol. 148 (3): 155–159. | Hydes, T. et al. (2018) IL-12 and IL-15 induce the expression of CXCR6 and CD49a on peripheral natural killer cells. Immun. Inflamm. Dis. 6 (1): 34–46.
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CD159c (NKG2C) Antibody, anti-human, Biotin, REAfinity™, 30 tests in 60 µL
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