- 询价
- Miltenyi Biotec
- 德国
- 130-112-128
- 2025年12月09日
- Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry, Mass cytometry
- human cell line
- human, non-human primate
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
CD163
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，4-8℃
- 克隆性：
REA812
- 标记物：
PE
- 适应物种：
human, non-human primate
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry, Mass cytometry
- 浓度：
1:50
- 抗体英文名：
CD163 Antibody, anti-human, REAfinity™
- 抗体名：
CD163 Antibody, anti-human, REAfinity™
- 规格：
100 tests in 200 µL
Identification and enumeration of CD163+ cells by flow cytometryClone REA812 recognizes the human CD163 antigen, a single-chain transmembrane protein also known as hemoglobin scavenger receptor or M130. It is expressed by mature tissue macrophages and peripheral blood monocytes. The expression of CD163 is up-regulated in vitro and in vivo by anti-inflammatory mediators such as interleukin 10 (IL-10) and (gluco)corticosteroid and is shed to blood upon inflammatory activation of macrophages. CD163 functions as a high affinity scavenger receptor for the complex of haemoglobin and haptoglobin. Depending on the ligand, crosslinking of CD163 initiates signal transduction leading to the production of proinflammatory cytokines Il-1ß, IL-6, and GM-CSF or the anti-inflammatory cytokine IL-10. | Additional information: Clone REA812 displays negligible binding to Fc receptors.
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文献和实验该产品被引用文献
Pulford, K. et al. (1992) A monocyte/macrophage antigen recognized by the four antibodies GHI/61, Ber-MAC3, Ki-M8 and SM4. Immunology 75 (4): 588–595. | Law, S. K. et al. (1993) A new macrophage differentiation antigen which is a member of the scavenger receptor superfamily. Eur. J. Immunol. 23 (9): 2320–2325. | Ritter, M. et al. (2001) Interaction of CD163 with the regulatory subunit of casein kinase II (CKII) and dependence of CD163 signaling on CKII and protein kinase C. Eur. J. Immunol. 31 (4): 999–1009. | Kristiansen, M. et al. (2001) Identification of the haemoglobin scavenger receptor. Nature 409 (6817): 198–201. | Burdo, T. H. et al. (2011) Soluble CD163 made by monocyte/macrophages is a novel marker of HIV activity in early and chronic infection prior to and after anti-retroviral therapy. J. Infect. Dis. 204: 154–163.
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CD163 Antibody, anti-human, PE, REAfinity™, 100 tests in 200 µL
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