- 询价
- Miltenyi Biotec
- 德国
- 130-118-976
- 2025年12月09日
- Flow cytometry
- human cell line
- human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
CD137L (4-1BBL)
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，2-8℃
- 克隆性：
REA254
- 标记物：
PE-Vio 770
- 适应物种：
human
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry
- 浓度：
1:50
- 抗体英文名：
CD137L (4-1BBL) Antibody, anti-human, REAfinity™
- 抗体名：
CD137L (4-1BBL) Antibody, anti-human, REAfinity™
- 规格：
100 tests in 200 µL
Identification and enumeration of CD137L (4-1BBL)+ cells by flow cytometryClone REA254 recognizes the CD137L antigen, a type II transmembrane glycoprotein belonging to the TNF superfamily, which is also known as 4-1BB ligand or tumor necrosis factor ligand superfamily member 9. CD137L is expressed on a variety of antigen-presenting cells, including dendritic cells (DCs), B cells, and macrophages as well as on activated T Lymphocytes. CD137L cross-links its receptor, CD137, which is expressed on activated T cells, and co-stimulates T cell activities. Signaling through interaction with CD137 by soluble CD137L has been shown to cause T cell–expansion, cytokine induction, and upregulation of antiapoptotic genes, and to prevent activation-induced cell death. In monocytes, macrophages, and DCs, CD137L signaling induces activation, migration, survival, and differentiation. The role of CD137 signaling has been studied in several autoimmune processes, including rheumatoid arthritis, experimental autoimmune encephalomyelitis, and systemic lupus erythematosus. | Additional information: Clone REA254 displays negligible binding to Fc receptors. |
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文献和实验该产品被引用文献
Alderson, M. R. et al. (1994) Molecular and biological characterization of human 4-1BB and its ligand. Eur. J. Immunol. 24 (9): 2219–2227. | Shao, Z. et al. (2011) CD137 ligand, a member of the tumor necrosis factor family, regulates immune responses via reverse signal transduction. J Leukoc Biol 89: 21–29. | Wang, C. et al. (2009) Immune regulation by 4-1BB and 4-1BBL: complexities and challenges. Immunol. Rev. 229 (1): 192–215. | Vinay, D. S. et al. (2012) Immunotherapy of cancer with 4-1BB. Mol. Cancer Ther. 11: 1062–1070.
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文献支持
CD137L (4-1BBL) Antibody, anti-human, PE-Vio® 770, REAfinity™, 100 tests in 200 µL
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