- 询价
- Miltenyi Biotec
- 德国
- 130-123-030
- 2025年12月09日
- Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- human cell line
- mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
CD125 (IL-5Rα)
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，2-8℃
- 克隆性：
REA343
- 标记物：
PE-Vio 615
- 适应物种：
mouse
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- 浓度：
1:50
- 抗体英文名：
CD125 (IL-5Rα) Antibody, anti-mouse, REAfinity™
- 抗体名：
CD125 (IL-5Rα) Antibody, anti-mouse, REAfinity™
- 规格：
30 µg in 200 µL
Identification and enumeration of CD125 (IL-5Rα)+ cells by flow cytometryClone REA343 recognizes the mouse CD125 antigen, a single-pass type I membrane protein, also known as interleukin-5 receptor subunit α (IL-5Rα). The IL-5 receptor is a heterodimer composed of a ligand specific α subunit and a signal transducing β subunit which is shared by the receptors for IL-3, GM-CSF, and IL-5. CD125 is expressed on eosinophils, basophils, and B cells. IL-5 is a conserved hematopoietic cytokine which is mainly produced by Tʜ2 cells after stimulation with antigens, and by mast cells upon stimulation with an allergen/IgE complex or a calcium ionophore. The overexpression of IL-5 in vivo significantly increases the numbers of eosinophils and B cells, while mice lacking the functional gene for IL-5 display various developmental and functional impairments in the B cell and eosinophil lineages. | Additional information: Clone REA343 displays negligible binding to Fc receptors. |
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文献和实验该产品被引用文献
Takaki, S. et al. (1990) Molecular cloning and expression of the murine interleukin-5 receptor. EMBO J. 9 (13): 4367–4374 . | Mao, H. et al. (2006) Effect of interleukin-5 receptor-alpha short hairpin RNA-expressing vector on bone marrow eosinophilopoiesis in asthmatic mice. Adv. Ther. 23 (6): 938–956. | Kusano, S. et al. (2012) Structural basis of interleukin-5 dimer recognition by its α receptor. Protein Sci. 21 (6): 850–864.
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文献支持
CD125 (IL-5Rα) Antibody, anti-mouse, PE-Vio® 615, REAfinity™, 30 µg in 200 µL
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