CD122 (IL-2Rβ) Antibody, anti-

Identification and enumeration of CD122 (IL-2Rβ)+ cells by flow cytometryClone REA1015 recognizes the murine CD122 70–75 kDa cell surface glycoprotein, also known as interleukin-2 receptor beta chain (IL-2Rβ). CD122 is constitutively expressed on mouse NK cells and at a lower level on subsets of T cells, B cells, monocytes, and macrophages. CD122 can associate with the common γ subunit (γc, CD132) alone or with the γc subunit and the IL-2Rα subunit (CD25), resulting in intermediate or high affinity IL-2 receptor complexes. CD122 expression levels can be upregulated by activation. Clone REA1015 interferes with binding of IL-2 to the receptor and can be used to deplete CD122+ cells. | Additional information: Clone REA1015 displays negligible binding to Fc receptors.