CD116 Antibody, anti-human, Vi

Identification and enumeration of CD116+ cells by flow cytometryClone REA211 recognizes CD116, the α subunit of GM-CSF receptor, which serves as a receptor for GM-CSF cytokine. GM-CSF is involved in innate and adaptive immune responses to infection, stimuli such as presence of LPS, and inflammatory diseases, such as asthma, rheumatoid arthritis, and multiple sclerosis. The GM-CSF receptor comprises of cytokine-specific α subunit, CD116, and βc subunit, which is a common subunit shared by interleukin-3 (IL-3) and IL-5. The human CD116 is a 378 residue glycoprotein with an extracellular N-terminal Ig-like domain, two fibronectin (FnIII) domains, and a 54 residue intracellular domain. Expression of CD116 is found on myeloid cells including monocytes, macrophages, neutrophils, eosinophils, dendritic cells, fibroblasts, endothelial cells, and myeloid leukemias. | Additional information: Clone REA211 displays negligible binding to Fc receptors. |