TIMP-3 Antibody, anti-human, P

Identification and enumeration of TIMP-3+ cells by flow cytometryClone REA417 recognizes the human tissue inhibitor of metalloproteinases 3 (TIMP-3) antigen, an extracellular matrix bound protein which is also known as MIG-5. TIMP-3 is expressed ubiquitously and is induced in response to mitogenic stimulation. It is a member of a family of endogenous matrix metalloproteinases inhibitors, of which there are currently four members (TIMP-1 through TIMP-4). By virtue of their matrix metalloproteinases inhibitory activity, TIMP family members have a potentially important function in regulating matrix composition and thereby affect a wide range of physiological processes including cell growth, invasion, migration, angiogenesis, transformation, and apoptosis. TIMP-3 complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor. Mutations in TIMP-3 are associated with Sorsby fundus dystrophy, a macular degenerative disease manifested by sudden loss of visual acuity in the third to fourth decades of life due to choroidal (submacular) neovascularization. | Additional information: Clone REA417 displays negligible binding to Fc receptors.